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Open AccessArticle

Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development

FONDAP Center for Genome Regulation (CGR), Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, ?u?oa, Santiago 7800003, Chile
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(3), 925;
Received: 7 October 2019 / Revised: 2 November 2019 / Accepted: 6 November 2019 / Published: 31 January 2020
(This article belongs to the Section Molecular Biology)
Transfer RNAs (tRNAs) are the most post-transcriptionally modified RNA species. Some of these modifications, especially the ones located in the anti-codon loop, are required for decoding capabilities of tRNAs. Such is the case for 5-methoxy-carbonyl-methyl-2-thio-uridine (mcm5s2U), synthetized by the Elongator complex. Mutants for its sub-units display pleiotropic phenotypes. In this paper, we analyze the role of elp3 (Elongator catalytic sub-unit) in zebrafish development. We found that it is required for trunk development; elp3 knock-down animals presented diminished levels of mcm5s2U and sonic hedgehog (Shh) signaling activity. Activation of this pathway was sufficient to revert the phenotype caused by elp3 knockdown, indicating a functional relationship between Elongator and Shh through a yet unknown molecular mechanism. View Full-Text
Keywords: elongator complex; tRNA modification; zebrafish elongator complex; tRNA modification; zebrafish
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Rojas-Benítez, D.; L. Allende, M. Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development. Int. J. Mol. Sci. 2020, 21, 925.

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