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Open AccessArticle

Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development

FONDAP Center for Genome Regulation (CGR), Facultad de Ciencias, Universidad de Chile, Las Palmeras 3425, ?u?oa, Santiago 7800003, Chile
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Int. J. Mol. Sci. 2020, 21(3), 925; https://doi.org/10.3390/ijms21030925
Received: 7 October 2019 / Revised: 2 November 2019 / Accepted: 6 November 2019 / Published: 31 January 2020
(This article belongs to the Section Molecular Biology)
Transfer RNAs (tRNAs) are the most post-transcriptionally modified RNA species. Some of these modifications, especially the ones located in the anti-codon loop, are required for decoding capabilities of tRNAs. Such is the case for 5-methoxy-carbonyl-methyl-2-thio-uridine (mcm5s2U), synthetized by the Elongator complex. Mutants for its sub-units display pleiotropic phenotypes. In this paper, we analyze the role of elp3 (Elongator catalytic sub-unit) in zebrafish development. We found that it is required for trunk development; elp3 knock-down animals presented diminished levels of mcm5s2U and sonic hedgehog (Shh) signaling activity. Activation of this pathway was sufficient to revert the phenotype caused by elp3 knockdown, indicating a functional relationship between Elongator and Shh through a yet unknown molecular mechanism. View Full-Text
Keywords: elongator complex; tRNA modification; zebrafish elongator complex; tRNA modification; zebrafish
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Rojas-Benítez, D.; L. Allende, M. Elongator Subunit 3 (Elp3) Is Required for Zebrafish Trunk Development. Int. J. Mol. Sci. 2020, 21, 925.

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