Table of Contents
Cancers, Volume 12, Issue 6 (June 2020) – 356 articles
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Cover Story (view full-size image) Clear cell renal cell carcinoma (ccRCC) is the most aggressive subtype of kidney cancer and up to [...] Read more. Clear cell renal cell carcinoma (ccRCC) is the most aggressive subtype of kidney cancer and up to 40% of patients submitted to surgery will relapse. Therefore, there is an urgent need to determine prognosis biomarkers. We studied the potential of an extracellular vesicle (EV)-derived microRNA profile as a prognostic biomarker in ccRCC. We focused on plasma EVs from patients with localized (before and after surgery) and metastatic disease. After surgery, EV-derived hsa-miR-301a-3p levels decreased whereas hsa-miR-1293 EV-derived levels increased and those levels remained stable during follow-up. When compared to follow-up patients, metastatic patients presented higher EV-derived hsa-miR-301a-3p and lower hsa-miR-1293. These results suggest that EV content varies depending on the presence or absence of ccRCC and that EV-derived hsa-miR-301a-3p and hsa-miR-1293 may be potential prognostic biomarkers. View this paper.